Vibrational Spectroscopy for Medical Diagnosis

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Vibrational Spectroscopy for Medical Diagnosis

Cancer is the second largest cause of death (after heart disease) in North America and Europe. Statistics from many countries serve constantly to inform us of how prevalent cancer is worldwide, even though one particular variation may be more predominant is one geographical region than another. The Traumatic cost in human lives, the dramatic cost of treatment and the need for rapidly advancing diagnoses and improving diagnostic methods for cancer, are clear for all to see. Current histopathological techniques for the detection and classification of cancer often lead to ambiguous diagnoses. Infrared and Raman spectroscopy have the potential to provide fast, accurate complementary techniques for the detection of many different forms of cancer. This book contains ten state-of-the-art chapters on the application of these techniques to the detection and classification of prostate, lymphatic, cervical, head and neck, and esophageal cancers, as well as reports on the application of vibrational spectroscopy to the study of individual human cells, and the identification of micro-organisms and erythrocytes, which should be of importance to spectroscopists and medical professionals alike.

This book provides an up-to-date account of the practical means, applications and potential of mid-infrared and Raman spectroscopy for the medical diagnosis of diseased tissue and cells. It will be of significant interest both to vibrational spectroscopists involved in developing technique for medical diagnosis, and to clinicians, histopathologists, medical practitioners and students working in the field, with whom the spectroscopists must work closely in multi-disciplinary teams.

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Contents

Introduction to Spectral Imaging, and Applications to Diagnosis of Lymph Nodes
Infrared and Raman Microspectroscopic Studies of Individual Human Cells
Infrared Spectroscopy in the Identification of Microorganisms
Antemortem Identification of Transmissible Spongiform Encephalopathy (TSE) from Serum by Mid-IR Spectroscopy
Head and Neck Cancer: A Clinical Overview, and Observations
Synchrotron-sourced Mid-infrared Spectroscopy Investigations
Infrared Spectroscopic Imaging Protocols for High-throughput Histopathology
Spectral Histopathology of the Human Cervix
Raman Spectroscopy as a Potential Tool for Early Diagnosis of Malignancies in Esophageal and Bladder Tissues
Neuro-oncological Applications of Infrared and Raman Spectroscopy
Resonance Raman Spectroscopy of Erythrocytes
Glossary
Appendix: Infrared and Raman Spectra of Selected Cellular
Components
Index