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       IM Publications LLP :: NIR Spectroscopy :: Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries, 2nd Edn

 

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Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries, 2nd Edn
Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries, 2nd Edn 
In this new edition all of the original chapters have been updated and revised, and new chapters covering the important topics of sampling, NMR, fluorescence, and acoustic chemometrics have been added.

The use of real or near real time measurement of chemical production process parameters as the basis for achieving control or optimisation of a manufacturing process has wide application in the petrochemical, food and chemical industries. Process analytical chemistry (PAC), or process analytical technology (PAT) as it has recently been called, is now being deployed in the pharmaceutical industry, where is is seen as a technology that can help companies to improve their conformity with manufacturing compliance requlations.

The objective of this book is to provide a starting point for implementing process analytical chemistry tools in process monitoring applications or as part of a total quality management system. Writen from the perspective of the spectroscopist required to implant PAT tools in a process environment, attention is focussed on measurements that are made 'in process' at-line or off-line, providing data on product during manufacture. With chapters covering the key spectroscopic tools, their applications in the pharmaceutical and chemical industries and basic chemometrics, the novice can quickly develop a sound understanding of the most practical technologies and applications. Implementation strategies are fully covered and address some of the critical issues that need to be tackled when setting up a PAT project - including choosing a project with a sound business justification in the first place.

The book provides an excellent first port of call for chemists, chemical and process engineers, and analytical chemists working on process development, scale-up and production in the pharmaceutical, fine and specialty chemicals industries, as well as for academic chemistry, chemical engineering, chemometrics and pharmaceutical science research groups focussing on PAT. It deserves to be found in every library that serves those who are active in the field of Process Analytical Technology. The layout of the book is well conceived, making it easy for the reader to quickly flip back and forth.

It is recommend to any new post-graduate student or novice seeking a sound understanding of the PAT area.
 
 
Contents

  • Overview of Process Analysis and PAT: Introduction and Execution of Process Analysis Projects (Jason E. Dickens)
  • Implementation of Process Analytical Technologies (Robert Guenard,Gert Thurau))
  • Process Sampling: Theory of Sampling - the Missing Link in Process Analytical Technologies (PAT) (Kim H. Esbensen,Peter Paasch-Mortensen)
  • UV-visible Spectroscopy for On-line Analysis (Marcel A. Liauw, Lewis C. Baylor,Patrick E.O'Rourke)
  • Near-infrared Spectroscopy for Process Analytical Technology: Theory, Technology and Implementation (Michael B. Simpson)
  • Infrared Spectroscopy for Process Analytical Applications (John P.Coates)
  • Raman Spectroscopy (Nancy L. Jestel)
  • Near-infrared Chemical Imaging for Product and Process Understanding (E.Neil Lewis, Joseph W, Schoppelrei, Lisa Makein, Linda H. Kidder, Eunah Lee)
  • Acoustic Chemometric Monitoring of Industrial Production Processes (Maths Halstensen, Kim H. Esbensen)
  • Process NMR Spectroscopy:Technology and On-lin Applications (John C. Edwards, Paul J. Giammatteo)
  • Fluorescent Sensing and Process Analytical Applications (Jason E. Dickens)
  • Chemometrics in Process Analytical Technology (PAT) (Charles E. Miller)
  • On-line PAT Applications of Spectroscopy in the Pharmaceutical Industry (Brandye Smith-Goettler)
  • NIR spectroscopy in Pharmaceutical Analysis: Off-line and At-line PAT Applications (Marcelo Blanco Romia, Manel Alcala Bernardez)
  • Near-infrared Spectroscopy (NIR) as a PAT Tool in the Chemical Industry: Added Value and Implementation Challenges (Ann M. Brearley, Susan J. Foulk)
  • Future Trends for PAT for Increased Processs Understanding and Growing Applications in Biomanufacturing (Katherine A. Bakeev, Jose C. Menezes)
  • Index

Details
 
AUTHOR(S)/ED(S) Katherine A. Bakeev (Ed)
BINDING Hardback
PUBLISHED April 2010
NO. PAGES xix + 576
AVAILABILITY In stock for immediate despatch

Price:
£125.00

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