https://www.euro-online.org/enog/inoc2007/Papers/mac-slots.html https://www.euro-online.org/enog/inoc2007/Papers/m https://www.euro-online.org/enog/inoc2007/Papers/mac-slots.html

IASIM 2018 Advertisement

NIR spectra of amine compound and its salts

jcg2000's picture
Forums: 

Dear All:
Can we use NIR to differentiate different salts of an amine compound, say, amphetamine sulphate, amphetamine hydrochloride, and amphetamine phosphate? Has anyone collected NIR spectra of these salts and made a comparision? It seems to me NIR should not tell the difference between the different types of salt of the same amine compound. But I do notice that these salts show different FTIR spectra. Please refer to http://www.swgdrug.org/Monographs/AMPHETAMINE.pdf for infrared spectra of the amphetamine salts. Is NIR also sensitive to the anionic part of an amine salt?
 
Thanks in advance!
Jerry Jin

Sheelagh Halsey's picture

I have looked at various salts, but not the particular ones you mention. One that comes to mind was a compound as a free base, hydrochloride and a tartrate, these all had significantly different spectra.
Regards
Sheelagh