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David Semmes (dsemmes)
New member
Username: dsemmes

Post Number: 3
Registered: 6-2010
Posted on Wednesday, June 23, 2010 - 6:55 am:   

Thanks Henk! The probe I have has an expensive stainless steel/sapphire barrel, and quartz would certainly be a more reasonable option. Can you tell me the source of your quartz tips? Do you know whether they are availble for reflectance?

Many thanks,

David
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Gabi Levin (gabiruth)
Senior Member
Username: gabiruth

Post Number: 37
Registered: 5-2009
Posted on Wednesday, June 23, 2010 - 3:53 am:   

OOPS - my e-mail is hidden
please write to [email protected]

Gabi Levin
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Gabi Levin (gabiruth)
Senior Member
Username: gabiruth

Post Number: 36
Registered: 5-2009
Posted on Wednesday, June 23, 2010 - 3:52 am:   

Hi guys,

It seems that somewhere in he FDA people are going overboard. With the exception of possibly highly potent actives, the whole parade about the cleaning of the probe is getting out of hand. In such cases, the better idea is to have a probe dedicated to that specific active ingredient, and that's it.
In all other cases, cleaning of sapphire tips of diffuse reflectance probes is an easy thing and can be done with confidence. Users all across the industry have done that for years. Using a sleeve will always introduce another parameter- is the spectrum of the sleeves from batch A identical with batch B, C etc? Is the thicknes of the sleeve same? how much variability the sleeve will introduce and what can we do about it. It is same issue as with ID through the poly bag. What do you do if a peak of the sleeve happens to practically coincide with that of the material etc.
The use of dedicated probes for highly potent actives can be cheaper and safer than any other approach over the long run.
For more information on easily exchanged probes please write to me to the mail listed in the details.
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Henk-Jan Ramaker (pieranja)
New member
Username: pieranja

Post Number: 3
Registered: 7-2006
Posted on Wednesday, June 23, 2010 - 2:53 am:   

David,

That is an interesting question! Recently, we have tested a disposable tip made of quartz glass. It can be used in transflection mode. I do not know of any plastic disposable sleeves, so i'm very interested if such sleeves exist. Quartz glass has better 'look through' properties I would say, but are probably more expensive compared to a plastic one.
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David Semmes (dsemmes)
New member
Username: dsemmes

Post Number: 1
Registered: 6-2010
Posted on Tuesday, June 22, 2010 - 2:17 pm:   

Does anyone have experience they can share on addressing the cleaning of NIR probes used for ID-testing for QA departments in regulated environments? For example, does anyone know of a supplier of disposable plastic probe sleeves of a known performance? Can anyone share experience on successfully addressing or alleviating QA concerns without excessive cleaning validations? I understand Glad Wrap works fine, but QA would prefer a product specifically intended for preventing contamination by the probe. Thanks for any help you can share!

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