| Author | Message | ||
     venkatarman (venkynir) Senior Member Username: venkynir Post Number: 66 Registered: 3-2004 |
Dear Levin; Your word : I got my password recovered, so you will be suffering my comments again. Not at all .We missed you.We will take your comments in positve direction and work for better. This uniformity ,blending done quit long time before in our country (INDIA). The grinding of Bengal grams paste for preparation of vada was one of the typical examble and applicaiton. More water it is dangerous , uniformity yield qood quality of the products( Vada here) was determined during blending by feel touch. The property of bengal gram also various with different geographical location . By touching and feeling the house wife report the end point of blending uniformity. | ||
| Gavriel Levin (levin) Senior Member Username: levin Post Number: 58 Registered: 1-2006 |
Hi guys, I got my password recovered, so you will be suffering my comments again. About the vitamins - from my humble experience in reading labels on bottles of all kinds of "health products" (healthy or not, they claim to be so) the concentration of most vitamins is quite low - mostly well below 0.1 weight %. In most cases such low concentrations will not respond too well to uniformity tests performed by NIR. Hopefully the levels in question are higher and will allow monitoring by NIR, but since I don't know the levels, I can only hope. To blend uniformity - I have accumulated very large base of experience and there are 3 different ways of looking at it without quantitative knowledge: 1. Moving block standard deviation - an algorithm we created long ago for a very large pgharma company and is widely used by several such companies. 2. Euclidian distance between consecutive rotations - this algorithm calculates ED between consecutive rotations - we can also use small blocks or moving blocks for that purpose. 3. Euclidian distance to target spectrum - in that case the ED are calculated to a target spectrum representing a well blended mix. Here we can also do blocks. All these methods are available and if anyone wishes more information I will be glad to provide as it is not the suitable stage for such communication due to commecrial nature. Gabi Levin Brimrose | ||
| raphael beauget (raph) Junior Member Username: raph Post Number: 8 Registered: 4-2007 |
Dear Ivas, Nir could be used only for realize blend uniformity. Do you need some quantitative informations or not ? Because if you don't need quantitative informations ! It's possible to collect spectra of your final blend (reference set) and after compare spectra of different locations of your blender with these reference spectra. if Standard deviation between these location is under the threshold (generally 5%), your blend could be considered as uniform. Regards | ||
| iyas (iyas) Junior Member Username: iyas Post Number: 10 Registered: 7-2007 |
dear venkynir dear tony dear all thanks for your answerr the main topic is using the nir in homgeneity test in process validationas an indactor for the bulk powders in mixture of b1 , b6 b12 the tab.ets yes have been analysed 6months till 1-2 years tthere stability is fully studied i think can you guide me | ||
| venkatarman (venkynir) Senior Member Username: venkynir Post Number: 61 Registered: 3-2004 |
Dear Toney ; Old is old but as per pharamcetical the value will retained its propety (ingradient value) for time period Is it ?. I do agree that particle size plays a vital role. If it is crushed and segregated to unifrom particle size, we may have some feasiblity (quality) study for methods and model building . Is it ? | ||
| Tony Davies (td) Moderator Username: td Post Number: 173 Registered: 1-2001 |
Hello Iyas, It is not ideal. You will have particle size differences and may be distribution differences. Some questions: 1) How many vitamins are in the bulk powder? 2) Have these tablets been analysed? 3) How old is old? 4) You may not be allowed to tell us which vitamins are in the mix but what do you know about there stability? At some point in time you will have to prepare your own carefully prepared samples from pure vitamins. If you just want to indicate the possibility of using NIR spectroscopy then your idea of using crushed tablets might work if none of my questions makes you need to think again. Good luck! Best wishes Tony | ||
| iyas (iyas) Junior Member Username: iyas Post Number: 9 Registered: 7-2007 |
Dear all I have a research topic in my Msc about using the nir as and indicator in process validation in homogeneity test for vitamins bulk powders My question can I use old samples of tablets and crushing them for assay as powder kin\d regards waiting for your answer |