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Hyesun P. McNulty (Hyesun)
Posted on Wednesday, July 14, 2004 - 7:07 am:   

Hello,

I am working for a biotech company in the vincinity of Boston. We are looking into using NIR to analyze biological tissues. Before make a commitment to purchase NIR unit, we would like to do some preliminary work with NIR. Does anybody know someone who can rent out NIR for a short period in Boston area?
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Bruce H. Campbell (Campclan)
Posted on Wednesday, July 14, 2004 - 12:05 pm:   

Hyesun,
The renting of an NIR spectrometer is not recommended UNLESS you have experience in using chemometrics OR want to take a relatively long time to learn chemometrics. I would recommend either having an equipment company do a preliminary evaluation for you or engage the services of a consultant. These preliminary evaluaitons normally are at no expense to you, except for your time and also sample prep as well as sample analyes by the "accepted" method. Another alternative is to send samples to someone who has a spectrometer, such as some consultants and independent companies have spectrometers together with experience in chemometrics.

Many instrument companies will also set up a leasing program with a minimum leasing period of several months.

I think you should initially contact instrument companies to discover if they will do preliminary examinations.
Bruce
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Melissa Kopp
Posted on Monday, July 19, 2004 - 2:06 pm:   

Dear Hyesun,

My name is Melissa Kopp and I work for Bruker Optics. We are a manufacturer of ir's and do rent/lease nir spectrometer's. PLease e-mail me at [email protected] or I can be reached by phone at 608-276-3800. Thanks and I look forward to hearing from you soon!

Melissa Kopp
Bruker Optics
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Bob Rosenthal
Posted on Tuesday, July 20, 2004 - 9:42 am:   

Carotenolds Measurement in Human Skin

There is currently a commercial instrument that measures the relative amount of carotenolds in the palm of the hand. The technology used is Raman Spectroscopy in the wavelength of 450 and 520 nm.

If my memory serves me right, approximately forty years ago the USDA determined the maturity of peanuts by measuring carotenolds at the same wavelengths using simple Delta OD math. I really have two questions: 1) Does anyone have experience measuring carotenolds using NIR type approaches and 2) Does it appear feasible to use the NIR technique at the shorter wavelengths to provide a meaningful measure of the carotenolds content in, for example, the palm of the hand?

Bob Rosenthal
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Gabi Levin
Posted on Wednesday, July 21, 2004 - 12:29 am:   

Hi Hyesun,

Since it was already done I will add:

Please contact Igor Nazarov - at Brimrose Corp.

[email protected] - (or 410 931 7200) for specific deatils on feasibility and rental.

On the not so commercial side -

Biological tissues are so sensitive to handling history before the measurement is done that it is practically not recommended to ship samples.

Even less sensitive samples such as ground fresh fruits need freezing and then the post defrosting handling is very important.

My suggestion is to have the feasibility done on site, in your lab, where your lab techs will do all the handling in as much a reproducible way.

Once the feasibility shows sufficient reason to further invest, then go ahead and either rent or buy.

Important - if you do feasibility at your site - don't settle for few samples - it will be totally misleading. Once Brimrose (or any other supplier) is investing the time and expense to get to your site - spending more time running few tens of samples is a very worthwhile effort. Less than that will be throwing everybody's money away.


If you write to me with more specific details on what is it that you want to measure, and in what type of matrix, I will be able to use my past experience to give you a preliminary idea on the probability of success before even doing the feasibility.

Thanks,

Gabi Levin
My e-mail:
[email protected]

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