| Author | Message | ||
     Donald J Dahm (djdahm) Senior Member Username: djdahm Post Number: 88 Registered: 2-2007 |
As I was saying when the thing posted itself: My client found that the sampling in several places in the blender, and using a qualitative technique to determine when blending was �done� was an effective way to go. In order to �prove� that the composition was what they had hoped to put into the blender, the spectra needed to be corrected for scatter changes during blending. We wound up doing MLR, one component at a time. Since the materials had nice sharp peaks, that worked well. | ||
| Donald J Dahm (djdahm) Senior Member Username: djdahm Post Number: 87 Registered: 2-2007 |
Hey, Lee: It seems that you have an Engineering Project. Will you be building the equipment that you are designing? I don't really know anything about equipment design. As far as analysis goes, I have had a bitter experience trying to use quantitative data to determine blend effectiveness. It seems like since you know the components and they have to add up to 100%, that PCR should be a natural. However, the bulk density can change during blending. and horror of horrors, the particles can be changing size on you. | ||
| Gabi Levin (gabiruth) Senior Member Username: gabiruth Post Number: 88 Registered: 5-2009 |
Lee, The first and most important question is: 1. Do you want to do qualitative or quantitative work. Qualitative will only look at the progress of the blending, then at the ability to reach stable blend. Quantitative will try to answer also - do we have the right concentration and is it uniform. Next you want to examine different formulations and see if they blend nicely, or not. If you write to me, I will send you some example data on different behavior of different formulations. Gabi Levin Brimrose Corp. [email protected] | ||
| lee (doublel) Junior Member Username: doublel Post Number: 9 Registered: 8-2009 |
hello djdahm, I have red some papers about blending. And I have concluded some aspects that should be considered such as the blending equipment, the material system,the parameters of spectra collection, the number of monitoring points, the design of experiment and the method for establishing models. That's what I can conclude now. | ||
| Donald J Dahm (djdahm) Senior Member Username: djdahm Post Number: 86 Registered: 2-2007 |
Some of us who are college professors think a student should come up with intitial proposals on their own based on classwork, and then get their ideas criticized by an expert (hopefully your instructor). So what have you proposed? | ||
| lee (doublel) Junior Member Username: doublel Post Number: 8 Registered: 8-2009 |
hello everyone, I am a student and my project is about blending in pharmaceutical using NIR. And now I have to make a proposal for the project. Would anyone can give me some advice in making the proposal? Many thanks! from Lee |