Abstract
Journal of Near Infrared Spectroscopy
Volume 12 Issue 5, Pages 271–278 (2004)
doi: 10.1255/jnirs.435
The influence of spectral resolution on the quantitative near infrared spectroscopic determination of an active ingredient in a solid drug formulation
Olga Kolomiets and Heinz W.
Siesler*
Department of Physical Chemistry, University of Duisburg-Essen, D-45117 Essen, Germany
This short communication is intended to demonstrate the influence of spectral resolution on the quantitative determination of an active ingredient in a solid drug formulation by diffuse reflection near infrared spectroscopy. As model system we have chosen a mixture of the active ingredient acetylsalicylic acid (aspirin) with cellulose and starch as excipients.
Keywords: solid drug formulation, spectral resolution, near infrared spectroscopy
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