Abstract

European Journal of Mass Spectrometry
Volume 13 Issue 3, Pages 191–198 (2007)
doi: 10.1255/ejms.874

Fragmentation studies of monensin A and B in negative electrospray and nanospray tandem mass spectrometry

José N. Sousa-Junior,^a Paul J. Gates^b,* and Norberto P. Lopes^a,*
aFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café S/N, CEP 14040-903, Ribeirão Preto-SP, Brazil. E-mail: npelopes@fcfrp.usp.br
^bSchool of Chemistry, University of Bristol, Cantock’s Close, Bristol, BS8 1TS, United Kingdom. E-mail: paul.gates@bristol.ac.uk

This paper reports the first comparative study of the gas-phase fragmentation chemistry of monensin in negative ion mode electrospray and nanoelectrospray tandem mass spectrometry. The fragmentation was observed to occur at lower energies in nanoelectrospray than electrospray. The major product ions are proposed to be formed via an initial neutral elimination of methanol followed be subsequent fragmentation. The low-mass product ions were observed at the same m/z for both monensin A and B.

Keywords: monensin, negative electrospray ionisation, negative nanoelectrospray ionisation, gas-phase chemistry

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