Abstract

European Journal of Mass Spectrometry
Volume 8 Issue 5, Pages 337–349 (2002)
doi: 10.1255/ejms.517

Account: Towards an understanding of the mechanism of electron- capture dissociation: a historical perspective and modern ideas

Roman A. Zubarev,^* Kim F. Haselmann, Bogdan Budnik, Frank Kjeldsen and Frank Jensen
Department of Chemistry, University of Southern Denmark, Odense, Denmark

Electron-capture dissociation (ECD) is a new fragmentation technique that utilizes ion–electron recombination reactions. The latter have parallels in other research fields; revealing these parallels helps to understand the ECD mechanism. An overview is given of ECD-related phenomena and of the history of ECD discovery and development. Current views on the ECD mechanism are discussed using both published and new examples.

Keywords: electron capture dissociation, ion–electron reactions, fragmentation, peptides and proteins

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