Abstract

European Journal of Mass Spectrometry
Volume 3 Issue 2, Pages 93–104 (1997)
doi: 10.1255/ejms.7

Account: Mass spectrometry in the combinatorial chemistry revolution

Joseph A. Loo
Parke-Davis Pharmaceutical Research, Division of Warner–Lambert Company, Ann Arbor, MI 48105, USA

The integration of mass spectrometry and combinatorial chemistry is becoming commonplace in many laboratory settings. Combinatorial chemistry provides a means for synthesis of mixtures of large numbers of compounds, thereby greatly increasing the diversity of molecular architectures available for screening. Mass spectrometry is being utilized as a rapid and sensitive tool not only to characterize combinatorial libraries, but also to aid in the identification of active compounds.

Keywords: electrospray ionization (ESI), matrix- assisted laser desorption/ionization (MALDI), secondary ion mass spectrometry (SIMS),noncovalent complexes, beads, affinity selection, combinatorial library, mixture analysis, capillary electrophoresis, tandem mass spectrometry (MS/MS).

---

Full-text article (916 kB) (subscribers only)

Buy article on-line for £20 (get immediate access)

Alerting Service

 RSS Feed

Permalink: http://dx.doi.org/10.1255/ejms.7
QR Code (what is this?):

---