European Journal of Mass Spectrometry - Abstract of Letter: Liquid chromatography ion trap/time-of-flight mass spectrometric study on the fragmentation of an acetildenafil analogue

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European Journal of Mass Spectrometry
Volume 13 Issue 3, Pages 233–238 (2007)
doi: 10.1255/ejms.873

Letter: Liquid chromatography ion trap/time-of-flight mass spectrometric study on the fragmentation of an acetildenafil analogue

Peng Zou,^a,b Sharon Sze-Yin Oh,^b Kin-Har Kiang,^b Min-Yong Low^b and Hwee-Ling Koh^c,*
^aDivision of Pharmaceutics, College of Pharmacy, Ohio State University, 357 Parks Hall, 500W 12th Ave, Columbus, OH 43210, USA
^bCentre for Analytical Science, Health Sciences Authority, 11 Outram Road, Singapore 169078
^cDepartment of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543. E-mail: phakohhl@nus.edu.sg

ABSTRACT:

Liquid chromatography ion-trap time-of-flight mass spectrometry was employed to elucidate the fragmentation pathways of an analogue of acetildenafil. Based on the accurate masses of the parent ion, product ions and neutral losses of acetildenafil analogue, its fragmentation pathways were proposed. The information is useful for the on-line structural identification of unknown analogues of acetildenafil found as adulterants in herbal products.

Keywords: acetildenafil analogue, fragmentation pathway, LC/IT/ToF-MS, herbal product

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